Department of Chemistry , University of Konstanz , Universitätsstraße 10 , D-78457 Konstanz , Germany.
Biomacromolecules. 2019 Jan 14;20(1):294-304. doi: 10.1021/acs.biomac.8b01460. Epub 2018 Dec 13.
Nanoparticles with a covalently bound shell of carbohydrate or sulfate groups, respectively, and a polyethylene core were generated by Ni(II)-catalyzed aqueous copolymerization of ethylene with comonomers undec-10-en-1-yl sulfate, undec-10-en-1-yl β-d-glucoside or undec-10-en-1-yl α-d-mannoside, respectively. Via remote substituents of the catalyst, the degree of branching and consequently degree of crystallinity of the polyethylene core of the glyconanoparticles could be controlled. This in turn impacts particle shapes, from spherical to anisotropic platelets, as observed by cryo-transmission electron microscopy. Enzyme-linked lectin assays revealed the mannose-decorated nanocrystals to be efficient multivalent ligands for concavalin A.
分别通过 Ni(II)催化的乙烯与十一碳烯-10-基硫酸酯、十一碳烯-10-基 β-d-葡萄糖苷或十一碳烯-10-基 α-d-甘露糖苷的水溶液共聚反应，生成了分别带有糖基或硫酸根基共价键壳层和聚乙烯核的纳米颗粒。通过催化剂的远程取代基，可以控制糖纳米颗粒的聚乙烯核的支化程度，从而控制结晶度。这反过来又影响了颗粒的形状，从球形到各向异性的薄片，如通过冷冻传输电子显微镜观察到的那样。酶联凝集素分析表明，甘露糖修饰的纳米晶体是凝集素 A 的有效多价配体。
