靶向甘露糖受体的新型多价甘露糖苷的设计与合成。
Design and synthesis of novel multivalent mannosides targeting the mannose receptor.
作者信息
Yin Zhao-Jun, Li Qing, Meng Xiang-Bao, Li Zhong-Jun
机构信息
Department of Chemical Biology, School of Pharmaceutical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083, PR China.
出版信息
Carbohydr Res. 2007 Dec 28;342(18):2729-34. doi: 10.1016/j.carres.2007.08.017. Epub 2007 Aug 31.
According to the characteristics of C-type lectin-like domains in the mannose receptor (MR), a novel design of multivalent mannosides targeting the MR was accomplished. Beginning with a divalent mannoside as the sugar unit, a series of multivalent mannosides with variations in both valence and space were synthesized in a convergent approach. The synthetic multivalent mannosides are to be explored to study MR-sugar binding events.
根据甘露糖受体（MR）中C型凝集素样结构域的特点，完成了一种靶向MR的新型多价甘露糖苷的设计。从二价甘露糖苷作为糖单元开始，采用汇聚法合成了一系列在价态和空间上都有变化的多价甘露糖苷。将对合成的多价甘露糖苷进行探索，以研究MR与糖的结合事件。
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