Rispoli Vittorio, Golfrè Andreasi Nico, Penna Giovanna, Preda Francesca, Contini Eleonora, Sensi Mariachiara
Neurology Department Azienda Ospedaliero-Universitaria Arcispedale Sant'Anna, Cona Ferrara Italy.
Neurology Department Ospedale Bufalini Cesena Italy.
Mov Disord Clin Pract. 2018 Oct 25;5(5):542-545. doi: 10.1002/mdc3.12640. eCollection 2018 Sep-Oct.
Gait and balance disorders in advanced Parkinson's disease (aPD) heavily impact the disease burden. In this prospective observational open-label study, our aim was to evaluate the effectiveness of levodopa/carbidopa intestinal gel (LCIG) infusion on balance and gait over a long-term follow-up.
The motor status of 15 aPD patients with balance and gait symptoms was assessed with UPDRS (I-IV) and H&Y at baseline in OFF and ON conditions, and after 52 weeks of LCIG infusion. Berg Balance Scale (BBS), Tinetti Gait & Balance Score (TS), Gait and Falls Questionnaire (G&F-Q), FOG Questionnaire (FOG-Q), and New FOG Questionnaire (NFOG-Q) were used to specifically test balance and gait.
UPDRS, H&Y, BBS, TS, G&F-Q, FOG-Q, NFOG-Q improved significantly. All FOG types benefited from LCIG.
Our preliminary data show the beneficial effect of LCIG therapy not only on FOG, but also on gait and balance. Results need to be confirmed in larger cohort studies.
晚期帕金森病（aPD）的步态和平衡障碍严重影响疾病负担。在这项前瞻性观察性开放标签研究中，我们的目的是评估左旋多巴/卡比多巴肠凝胶（LCIG）输注在长期随访中对平衡和步态的有效性。
在基线时，对15例有平衡和步态症状的aPD患者在关期和开期使用统一帕金森病评定量表（UPDRS，I-IV）和 Hoehn-Yahr 分级（H&Y）评估运动状态，并在LCIG输注52周后再次评估。采用伯格平衡量表（BBS）、Tinetti步态与平衡评分（TS）、步态与跌倒问卷（G&F-Q）、冻结步态问卷（FOG-Q）和新冻结步态问卷（NFOG-Q）专门测试平衡和步态。
UPDRS、H&Y、BBS、TS、G&F-Q、FOG-Q、NFOG-Q均有显著改善。所有类型的冻结步态都从LCIG中获益。
我们的初步数据表明，LCIG治疗不仅对冻结步态有益，而且对步态和平衡也有益。结果需要在更大规模的队列研究中得到证实。
