Li Haitao, Liang Siquan, Yu Yang, Wang Yue, Cheng Yuanyuan, Yang Hechao, Tong Xiaoguang
Graduate School of Tianjin Medical University.
Department of Neurosurgery, Tianjin Huanhu Hosptial.
Medicine (Baltimore). 2020 May;99(19):e20154. doi: 10.1097/MD.0000000000020154.
To investigate the effect of multi-disciplinary teamwork on balance performance of Parkinson's disease (PD).Sixteen primary Parkinson's disease patients (8 male, 8 female) treated with bilateral subthalamic nucleus deep brain stimulation (STN-DBS) were included in the study. The median age of patients was 60.5 years; all patients were in the Hoehn&Yahr (H&Y) 3 stage; the median PD duration of the disease was 9 years. For each patient, multi-disciplinary teamwork treatment including DBS, medication, physical therapy and psychotherapy proceeded. levodopa equivalent daily dose (LEDD, mg/day), life quality (PDQ-39), Motor disability (MDS-UPDRSIII) and balance performance (MDS-UPDRS 3.12, Berg Balance Scale BBS, Limits of Stability LoS) were assessed in different time and status respectively: preoperation (Med-off, Med-on), postoperation (Stim-Off/Med-Off, Stim-On/Med-Off, Stim-On/Med-On), 6 months postoperation (Stim-On/ Med-Off, Stim-On/Med-On) and 12 months postoperation (Stim-On/Med-Off, Stim-On/Med-On).The LEDD, life quality (PDQ-39) continued to improve during the follow-up, statistical difference were found in both 6 months postoperation and 12 months postoperation compared with preoperation. The Motor disability (MDS-UPDRSIII), balance performance (MDS-UPDRS 3.12, BBS) and the LoS (target acquisition percentage, trunk swing angle standard deviation, time) showed significant improvement in Stim-On/med-Off 6 months postoperation and 12 months postoperation separately compared with Med-Off preoperation.Multi-disciplinary teamwork for PD patients with STN-DBS could improve balance performance.
探讨多学科团队合作对帕金森病（PD）平衡能力的影响。本研究纳入了16例接受双侧丘脑底核深部脑刺激（STN-DBS）治疗的原发性帕金森病患者（8例男性，8例女性）。患者的中位年龄为60.5岁；所有患者均处于Hoehn&Yahr（H&Y）3期；疾病的中位病程为9年。对每位患者进行了包括DBS、药物治疗、物理治疗和心理治疗在内的多学科团队合作治疗。分别在不同时间和状态下评估左旋多巴等效日剂量（LEDD，mg/天）、生活质量（PDQ-39）、运动功能障碍（MDS-UPDRSIII）和平衡能力（MDS-UPDRS 3.12、伯格平衡量表BBS、稳定性极限LoS）：术前（关期、开期）、术后（刺激关/药关、刺激开/药关、刺激开/药开）、术后6个月（刺激开/药关、刺激开/药开）和术后12个月（刺激开/药关、刺激开/药开）。随访期间LEDD、生活质量（PDQ-39）持续改善，术后6个月和12个月与术前相比均有统计学差异。运动功能障碍（MDS-UPDRSIII）、平衡能力（MDS-UPDRS 3.12、BBS）和LoS（目标获取百分比、躯干摆动角度标准差、时间）在术后6个月和12个月的刺激开/药关状态下分别与术前关期相比有显著改善。对接受STN-DBS治疗的PD患者进行多学科团队合作可改善平衡能力。
