a University of Texas at Austin College of Natural Sciences , Nutritional Sciences , Austin , TX , USA.
b University of Texas at Austin College of Education , Educational Psychology , Austin , TX , USA.
Leuk Lymphoma. 2019 Jun;60(6):1548-1556. doi: 10.1080/10428194.2018.1540043. Epub 2018 Dec 5.
Acute leukemia is a clonal malignant disorder that occurs when immature blast cells accumulate in bone marrow. Zinc (Zn) and copper (Cu) are related to normal lymphocyte maturation and immune function regulation. Selenium (Se) is protective against oxidative damage. The aim of this meta-analysis is to statistically synthesize results from studies that have investigated the levels of Zn, Cu, and Se in acute leukemia patients. The effect size, delta, was used to standardize the raw data. The robust variance estimation (RVE) method was performed to measure the pooled effect size and variance. Results suggest significant negative differences for levels of serum Zn ( < .05, delta = -1.21; 95% CI, -2.13--0.28) and Se ( < .05, delta = -1.84; 95% CI, -3.39--0.29) and significantly positive differences between serum Cu levels ( < .01, delta = 1.94; 95% CI, 1.02-2.87) in acute leukemia, as compared to the controls.
急性白血病是一种克隆性恶性疾病，当未成熟的原始细胞在骨髓中积累时就会发生。锌（Zn）和铜（Cu）与正常淋巴细胞成熟和免疫功能调节有关。硒（Se）可防止氧化损伤。本荟萃分析的目的是对研究急性白血病患者体内 Zn、Cu 和 Se 水平的研究结果进行统计学综合。使用效应量 delta 来标准化原始数据。采用稳健方差估计（RVE）方法测量合并效应量和方差。结果表明，与对照组相比，血清 Zn 水平（<.05，delta = -1.21；95%CI，-2.13--0.28）和 Se 水平（<.05，delta = -1.84；95%CI，-3.39--0.29）存在显著负差异，而血清 Cu 水平（<.01，delta = 1.94；95%CI，1.02-2.87）存在显著正差异。
