Mills Matthew J, Sarigul-Klijn Nesrin
Mechanical and AerospaceEngineering Department,University of California, Davis,2132 Bainer Drive,Davis, CA 95616e-mail:
J Biomech Eng. 2019 Mar 1;141(3). doi: 10.1115/1.4042183.
Mathematical models of the human spine can be used to investigate spinal biomechanics without the difficulties, limitations, and ethical concerns associated with physical experimentation. Validation of such models is necessary to ensure that the modeled system behavior accurately represents the physics of the actual system. The goal of this work was to validate a medical image-based nonlinear lumbosacral spine finite element model of a healthy 20-yr-old female subject under physiological moments. Range of motion (ROM), facet joint forces (FJF), and intradiscal pressure (IDP) were compared with experimental values and validated finite element models from the literature. The finite element model presented in this work was in good agreement with published experimental studies and finite element models under pure moments. For applied moments of 7.5 N·m, the ROM in flexion-extension, axial rotation, and lateral bending were 39 deg, 16 deg, and 28 deg, respectively. Excellent agreement was observed between the finite element model and experimental data for IDP under pure compressive loading. The predicted FJFs were lower than those of the experimental results and validated finite element models for extension and torsion, likely due to the nondegenerate properties chosen for the intervertebral disks and morphology of the young female spine. This work is the first to validate a computational lumbar spine model of a young female subject. This model will serve as a valuable tool for predicting orthopedic spinal injuries, studying the effect of intervertebral disk replacements using advanced biomaterials, and investigating soft tissue degeneration.
人体脊柱的数学模型可用于研究脊柱生物力学，而无需面对物理实验所带来的困难、限制和伦理问题。对此类模型进行验证是必要的，以确保建模系统的行为能够准确反映实际系统的物理特性。这项工作的目标是在生理力矩作用下，对一名20岁健康女性受试者基于医学图像的非线性腰骶部脊柱有限元模型进行验证。将运动范围（ROM）、小关节力（FJF）和椎间盘内压力（IDP）与实验值以及文献中经过验证的有限元模型进行了比较。本文提出的有限元模型与已发表的关于纯力矩作用下的实验研究和有限元模型吻合良好。对于7.5 N·m的施加力矩，屈伸、轴向旋转和侧方弯曲时的ROM分别为39°、16°和28°。在纯压缩载荷下，有限元模型与IDP的实验数据之间观察到了极佳的吻合度。预测的FJFs低于实验结果以及针对伸展和扭转情况经过验证的有限元模型，这可能是由于所选择的椎间盘非退化特性以及年轻女性脊柱的形态所致。这项工作首次对年轻女性受试者的腰椎计算模型进行了验证。该模型将成为预测脊柱骨科损伤、研究使用先进生物材料进行椎间盘置换的效果以及研究软组织退变的宝贵工具。
