2型糖尿病患者血清血管内皮生长因子浓度与糖化血红蛋白水平呈负相关。

SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION DECREASES IN CORRELATION WITH GLYCATED HEMOGLOBIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES.

作者信息

Kakhniashvili T, Tabagari-Bregvadze N, Dzvelaia Sh, Chikadze A, Kurashvili R

机构信息

Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary Disease Center "Diacor"; P. Sarajishvili Institute of Neurolog, Tbilisi, Georgia.

出版信息

Georgian Med News. 2018 Oct(283):55-58.

PMID:30516492

Abstract

Our aim was to compare serum vascular endothelial growth factor (VEGF) level in type 2 diabetes mellitus (T2DM) patients with comorbid OSA at screening and 6 month follow up visits. In the prospective cohort study following data were collected at screening visit: medical anamnesis; demographic and anthropometric data; Epworth sleepiness score data; laboratory (serum VEGF, complete blood count, biochemistry, immunology, complete urine test, including microalbuminuria) and instrumental investigation data (fundoscophy, laboratory polysomnography). At 6 months follow up visit we evaluated anthropometric data; Epworth sleepiness score; serum VEGF. Comparing VEGF level at screening and 6 month follow up visits showed significant decrease in VEGF level in both groups (P=0.0281 OSA+ and P=0.0278 OSA-). It was established direct correlation between decreased VEGF level and decreased HbA1c level (P=0.04696) and between decreased VEGF level and Epworth sleepiness score (P=0.0153) at 6 month follow up visit in OSA+ group. Our the study suggests that VEGF level decreases in parallel with diabetes compensation quality. Future researches are necessary to support this research.

摘要

我们的目的是比较2型糖尿病（T2DM）合并阻塞性睡眠呼吸暂停（OSA）患者在筛查时及随访6个月时的血清血管内皮生长因子（VEGF）水平。在前瞻性队列研究中，在筛查访视时收集了以下数据：病史；人口统计学和人体测量数据；爱泼华嗜睡量表评分数据；实验室检查（血清VEGF、全血细胞计数、生化、免疫、尿常规，包括微量白蛋白尿）和器械检查数据（眼底检查、实验室多导睡眠图）。在随访6个月时，我们评估了人体测量数据；爱泼华嗜睡量表评分；血清VEGF。比较筛查时和随访6个月时的VEGF水平，两组的VEGF水平均显著降低（OSA+组P=0.0281，OSA-组P=0.0278）。在OSA+组随访6个月时，发现VEGF水平降低与糖化血红蛋白（HbA1c）水平降低之间存在直接相关性（P=0.04696），且VEGF水平降低与爱泼华嗜睡量表评分之间也存在直接相关性（P=0.0153）。我们的研究表明，VEGF水平与糖尿病控制质量呈平行下降。未来需要进一步的研究来支持这项研究。