2型糖尿病合并阻塞性睡眠呼吸暂停患者血清血管内皮生长因子水平与微血管病变严重程度之间的关系

CONNECTION BETWEEN SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR LEVELS AND SEVERITY OF MICROANGIOPATHY IN PATIENTS WITH TYPE 2 DIABETES AND OBSTRUCTIVE SLEEP APNEA.

作者信息

Kakhniashvili T, Tabagari-Bregvadze N, Nikoleishvili L, Khuchua L, Kurashvili R

机构信息

Davit Tvildiani Medical University; Diabetes, Endocrine and Cardio-pulmonary Disease Center "Diacor"; P. Sarajishvili Institute of Neurology, Tbilisi, Georgia.

出版信息

Georgian Med News. 2018 Oct(283):51-54.

PMID:30516491

Abstract

Our aim was to evaluate the serum vascular endothelial growth factor (VEGF) level in type 2 diabetes patients with comorbid obstructive sleep apnea (OSA) and to compare it in connection with diabetic retinopathy and chronic kidney disease severity. In the prospective cohort study following data were collected: medical anamnesis; demographic and anthropometric data; laboratory (serum VEGF, complete blood count, biochemistry, immunology, complete urine test, including microalbuminuria) and instrumental investigation data (fundoscophy, laboratory polysomnography). From 232 analyzed patients 54 (23.27%) were placed in OSA+ group, 178-OSA- group Mean VEGF value in OSA+ group was significantly higher, than in OSA- group. Serum VEGF level in patients with diabetic retinopathy was signifcantly higher with OSA comorbidity. Pearson correlation coefficient between VEGF and diabetic retinopathy stages, VEGF and CKD stages was significant in both groups. Our study suggests, that the blood VEGF play an important role in microangiopathy severity in patients with T2DM, especially with OSA comorbily.

摘要

我们的目的是评估合并阻塞性睡眠呼吸暂停（OSA）的2型糖尿病患者的血清血管内皮生长因子（VEGF）水平，并将其与糖尿病视网膜病变和慢性肾脏病的严重程度进行比较。在这项前瞻性队列研究中，收集了以下数据：医学病史；人口统计学和人体测量数据；实验室检查（血清VEGF、全血细胞计数、生物化学、免疫学、尿常规检查，包括微量白蛋白尿）和器械检查数据（眼底检查、实验室多导睡眠图）。在232例分析患者中，54例（23.27%）被纳入OSA+组，178例纳入OSA-组。OSA+组的平均VEGF值显著高于OSA-组。合并OSA的糖尿病视网膜病变患者的血清VEGF水平显著更高。两组中VEGF与糖尿病视网膜病变分期、VEGF与慢性肾脏病分期之间的Pearson相关系数均具有显著性。我们的研究表明，血液VEGF在2型糖尿病患者，尤其是合并OSA的患者的微血管病变严重程度中起重要作用。