为什么有些器官同种移植物比其他的更能被接受：一个老问题的新见解。
Why some organ allografts are tolerated better than others: new insights for an old question.
机构信息
Department of Surgery, Massachusetts General Hospital.
Center for Transplantation Science.
出版信息
Curr Opin Organ Transplant. 2019 Feb;24(1):49-57. doi: 10.1097/MOT.0000000000000594.
Abstract
PURPOSE OF REVIEW
There is great variability in how different organ allografts respond to the same tolerance induction protocol. Well known examples of this phenomenon include the protolerogenic nature of kidney and liver allografts as opposed to the tolerance-resistance of heart and lung allografts. This suggests there are organ-specific factors which differentially drive the immune response following transplantation.
RECENT FINDINGS
The specific cells or cell products that make one organ allograft more likely to be accepted off immunosuppression than another are largely unknown. However, new insights have been made in this area recently.
SUMMARY
The current review will focus on the organ-intrinsic factors that contribute to the organ-specific differences observed in tolerance induction with a view to developing therapeutic strategies to better prevent organ rejection and promote tolerance induction of all organs.
摘要
目的综述
不同的器官移植物对同一耐受诱导方案的反应存在很大的可变性。这一现象的典型例子包括肾和肝移植物的原耐受特性与心和肺移植物的耐受抗性。这表明存在器官特异性因素，可在移植后不同地驱动免疫反应。
最近的发现
使一种器官移植物比另一种更容易在没有免疫抑制的情况下被接受的特定细胞或细胞产物在很大程度上尚不清楚。然而，最近在这一领域取得了新的进展。
总结
本综述将重点讨论导致耐受诱导中观察到的器官特异性差异的器官内在因素，以期制定治疗策略，更好地预防器官排斥反应并促进所有器官的耐受诱导。
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