Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.
Org Biomol Chem. 2018 Dec 12;16(48):9368-9372. doi: 10.1039/c8ob01262h.
Iron-catalyzed hydrosilylation of imines to amines using a well-defined iron complex is reported. This method employs relatively mild conditions, by reaction of imine, (EtO)3SiH in a 1 : 2 ratio in the presence of 1 mol% precatalyst ([BIAN]Fe(η6-toluene), 3, BIAN = bis(2,6-diisopropylaniline)acenaphthene) at 70 °C. A broad scope of imines was readily converted into the corresponding secondary amines without the need for precatalyst activators.
本文报道了一种使用定义明确的铁配合物实现亚胺的铁催化氢化硅烷化反应生成胺的方法。该方法条件较为温和，反应在 70°C 下，以 1:2 的摩尔比将亚胺与(EtO)3SiH 反应，在 1 mol%的前催化剂([BIAN]Fe(η6-甲苯)，3，BIAN = 双(2,6-二异丙基苯胺)菲咯啉)存在下进行。该方法具有广泛的底物适用性，无需使用前催化剂激活剂，即可将各种亚胺迅速转化为相应的仲胺。
