在水中对未保护的肽进行闭环复分解反应。
Ring-closing metathesis of unprotected peptides in water.
机构信息
Peptide Institute, Inc., Ibaraki, Osaka 567-0085, Japan.
出版信息
Org Biomol Chem. 2018 Dec 12;16(48):9364-9367. doi: 10.1039/c8ob02778a.
PMID:30516782
Abstract
Ring-closing metathesis (RCM) is an attractive reaction for the preparation of artificially designed peptides. Until now, RCM has been used for fully or partially protected peptides. Herein, the first RCM of unprotected peptides in water was achieved using a water-soluble Ru catalyst.
摘要
环化易位反应（RCM）是一种用于制备人工设计肽的有吸引力的反应。到目前为止，RCM 已用于完全或部分保护的肽。本文首次使用水溶性 Ru 催化剂在水中实现了未保护肽的 RCM。
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