Vieira Ilse Lisiane Viertel, Kupek Emil
Universidade Federal de Santa Catarina, Departamento de Saúde Pública, Florianópolis, SC, Brasil.
Epidemiol Serv Saude. 2018 Nov 29;27(4):e2017378. doi: 10.5123/S1679-49742018000400012.
to analyze the impact of pneumococcal conjugate vaccine (PCV10) on pneumonia hospital admissions among children in Santa Catarina, Brazil, 2006-2014.
this was an ecological study using data obtained from Brazilian National Health System Information Technology Department (Datasus) for 2006-2009 (pre-vaccination period) and 2010-2014 (post-vaccination period); time trends were evaluated using the Poisson regression coefficient.
in the comparison between pre- and post-vaccination periods, the percentage difference in the hospitalization rate for children under 1 year old ranged from -44.1% in the Western region to -1.4% in the Serrano Plateau region, and in children between 1-4 years old it ranged from -37.1% in the Northern Plateau region to 16.9% in the Serrano Plateau region (p<0.05); hospitalization rates in the state reduced by 23.3% in children under 1 year old and by 8.4% in those aged 1-4 years.
a significant reduction in the rate of pneumonia hospitalization in children under 1 year old age was found, suggesting the effectiveness of the vaccine in reducing hospitalizations.
分析2006 - 2014年巴西圣卡塔琳娜州肺炎球菌结合疫苗（PCV10）对儿童肺炎住院率的影响。
这是一项生态学研究，使用从巴西国家卫生系统信息技术部（Datasus）获取的2006 - 2009年（疫苗接种前时期）和2010 - 2014年（疫苗接种后时期）的数据；采用泊松回归系数评估时间趋势。
在疫苗接种前后时期的比较中，1岁以下儿童住院率的百分比差异在西部地区为-44.1%，在塞拉诺高原地区为-1.4%；1 - 4岁儿童的该差异在北部高原地区为-37.1%，在塞拉诺高原地区为16.9%（p<0.05）；该州1岁以下儿童住院率降低了23.3%，1 - 4岁儿童住院率降低了8.4%。
发现1岁以下儿童肺炎住院率显著降低，表明该疫苗在降低住院率方面有效。
