Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Nutrients. 2018 Dec 4;10(12):1917. doi: 10.3390/nu10121917.
Hypertension is a growing global epidemic. Developmental programming resulting in hypertension can begin in early life. Maternal nutrition status has important implications as a double-edged sword in the developmental programming of hypertension. Imbalanced maternal nutrition causes offspring's hypertension, while specific nutritional interventions during pregnancy and lactation may serve as reprogramming strategies to reverse programming processes and prevent the development of hypertension. In this review, we first summarize the human and animal data supporting the link between maternal nutrition and developmental programming of hypertension. This review also presents common mechanisms underlying nutritional programming-induced hypertension. This will be followed by studies documenting nutritional interventions as reprogramming strategies to protect against hypertension from developmental origins. The identification of ideal nutritional interventions for the prevention of hypertension development that begins early in life will have a lifelong impact, with profound savings in the global burden of hypertension.
高血压是一种日益严重的全球流行疾病。导致高血压的发育编程可能早在生命早期就开始了。母亲的营养状况具有重要意义，因为它是高血压发育编程的双刃剑。不平衡的母体营养会导致后代高血压，而在怀孕期间和哺乳期进行特定的营养干预可能是一种重新编程策略，可以逆转编程过程，预防高血压的发生。在这篇综述中，我们首先总结了支持母体营养与高血压发育编程之间联系的人体和动物数据。本文还介绍了营养编程引起高血压的常见机制。接下来是记录营养干预作为预防高血压发生的重新编程策略的研究，这些高血压起源于发育。确定用于预防从生命早期开始的高血压发展的理想营养干预措施将产生终身影响，对全球高血压负担产生深远影响。
