Central Marine Fisheries Research Institute, Cochin, India.
Nat Prod Res. 2020 May;34(10):1409-1416. doi: 10.1080/14786419.2018.1508150. Epub 2018 Dec 5.
Phytochemical investigation on the biologically active compounds of seaweed {(C. Agardh) E.Y. Dawson} (family Gracilariaceae) guided to the separation of a previously unreported abeo-labdane class of diterpenoid. The compound was characterized as methyl-16(13→14)-abeo-7-labdene-(12-oxo) carboxylate by extensive spectroscopic experiments, and comparison with the related compounds. The studied compound registered significantly greater activities against pro-inflammatory 5-lipoxygenase (IC 0.86 mg/mL) than that exhibited by non-steroidal anti-inflammatory agent ibuprofen (IC 0.92 mg/mL, < 0.05). Likewise, this compound exhibited comparable radical quenching (1, 1-diphenyl-2-picryl-hydrazil) activity (IC 0.66 mg/mL) as standard antioxidant agent -tocopherol (IC 0.62 mg/mL).
海藻{(C. Agardh) E.Y. Dawson}（江蓠科）生物活性化合物的植物化学研究指导了以前未报道的 abeo- 类贝壳杉烷二萜的分离。该化合物通过广泛的光谱实验，并与相关化合物进行比较，被表征为甲基-16(13→14)-abeo-7-贝壳杉烯-(12-氧代)羧酸酯。研究化合物对促炎 5-脂氧合酶的活性（IC 0.86 mg/mL）显著大于非甾体抗炎药布洛芬（IC 0.92 mg/mL， < 0.05）。同样，该化合物表现出与标准抗氧化剂 -生育酚（IC 0.62 mg/mL）相当的自由基猝灭（1, 1-二苯基-2-苦基肼）活性（IC 0.66 mg/mL）。
