Januário Adriana P, Félix Rafael, Félix Carina, Reboleira João, Valentão Patrícia, Lemos Marco F L
MARE-Marine and Environmental Sciences Centre, ESTM, Instituto Politécnico de Leiria, 2520-641 Peniche, Portugal.
REQUIMTE/LAQV, Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
Pharmaceutics. 2021 Nov 15;13(11):1930. doi: 10.3390/pharmaceutics13111930.
Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.
寻常痤疮（AV）是一种影响青少年和成年人的毛囊皮脂腺单位的慢性皮肤病。其病理生理学包括炎症、角质化增加、皮脂分泌、激素失调和细菌增殖等过程。自20世纪60年代以来，普通寻常痤疮一直用抗生素治疗，但菌株耐药性已经出现，这是至关重要的问题。大型藻类是具有生物活性物质的已知生产者，这些物质具有抗病毒、抗菌、抗氧化和抗炎等多种特性。特别是红藻富含多糖、酚类化合物、脂质、甾醇、生物碱和萜类等生物活性化合物，赋予它们抗氧化、抗菌和抗炎等活性。因此，探索海洋资源中的化合物可能是发现治疗寻常痤疮新方法的一种有吸引力的途径。这项工作的目的是通过回顾该疾病的主要治疗靶点，以及然后存在针对这些靶点具有生物活性的化合物或提取物，来概述红大型藻类在治疗寻常痤疮方面潜力的当前知识。
