Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, 32 Turan Avenue, Astana, 010000, Kazakhstan.
Department of Medicine, Nazarbayev University School of Medicine, 5/1 Kerey and Zhanibek Khans str., Astana, 010000, Kazakhstan.
Immunol Res. 2018 Dec;66(6):756-760. doi: 10.1007/s12026-018-9049-9.
The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10-17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). The main outcome was assessment of OCPs blood levels (correlating to pubertal development and sexual hormonal status) and IL-1 levels. The delayed sexual development and the hormonal profile in OCPs exposed female adolescents correlated to the blood levels of OCPs. Interestingly, serum IL-1α and IL-1β in girls living in contaminated areas correlated to OCPs blood levels as well. Both OCPs and IL-1 blood levels in exposed female adolescents resulted to be increased, but further research is required to establish if that might represent an additional factor contributing to puberty disorders and/or reproductive health issues.
本研究旨在通过观察性横断面研究评估有机氯农药 (OCPs) 对暴露于有机氯农药的女性青少年 IL-1 轴的潜在影响。该研究在哈萨克斯坦南部的 Sary-Agach 区（OCPs 暴露组女孩）和 Sairam 区（OCPs 未暴露对照组）进行。研究纳入了 524 名年龄在 10-17 岁的女性青少年（OCPs 暴露组，n=253；OCPs 未暴露组，n=271）。主要结局是评估 OCPs 的血液水平（与青春期发育和性荷尔蒙状态相关）和 IL-1 水平。暴露于 OCPs 的女性青少年的性发育延迟和激素特征与 OCPs 的血液水平相关。有趣的是，生活在污染地区的女孩的血清 IL-1α 和 IL-1β 与 OCPs 的血液水平也相关。暴露于 OCPs 的女性青少年的 OCPs 和 IL-1 血液水平均升高，但需要进一步研究以确定这是否可能是导致青春期障碍和/或生殖健康问题的另一个因素。
