有机氯农药暴露对女性青少年的影响：对性激素和白细胞介素-1 水平的潜在影响。
Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels.
机构信息
Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, 32 Turan Avenue, Astana, 010000, Kazakhstan.
Department of Medicine, Nazarbayev University School of Medicine, 5/1 Kerey and Zhanibek Khans str., Astana, 010000, Kazakhstan.
出版信息
Immunol Res. 2018 Dec;66(6):756-760. doi: 10.1007/s12026-018-9049-9.
The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10-17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). The main outcome was assessment of OCPs blood levels (correlating to pubertal development and sexual hormonal status) and IL-1 levels. The delayed sexual development and the hormonal profile in OCPs exposed female adolescents correlated to the blood levels of OCPs. Interestingly, serum IL-1α and IL-1β in girls living in contaminated areas correlated to OCPs blood levels as well. Both OCPs and IL-1 blood levels in exposed female adolescents resulted to be increased, but further research is required to establish if that might represent an additional factor contributing to puberty disorders and/or reproductive health issues.
本研究旨在通过观察性横断面研究评估有机氯农药 (OCPs) 对暴露于有机氯农药的女性青少年 IL-1 轴的潜在影响。该研究在哈萨克斯坦南部的 Sary-Agach 区（OCPs 暴露组女孩）和 Sairam 区（OCPs 未暴露对照组）进行。研究纳入了 524 名年龄在 10-17 岁的女性青少年（OCPs 暴露组，n=253；OCPs 未暴露组，n=271）。主要结局是评估 OCPs 的血液水平（与青春期发育和性荷尔蒙状态相关）和 IL-1 水平。暴露于 OCPs 的女性青少年的性发育延迟和激素特征与 OCPs 的血液水平相关。有趣的是，生活在污染地区的女孩的血清 IL-1α 和 IL-1β 与 OCPs 的血液水平也相关。暴露于 OCPs 的女性青少年的 OCPs 和 IL-1 血液水平均升高，但需要进一步研究以确定这是否可能是导致青春期障碍和/或生殖健康问题的另一个因素。
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