环状 RNA 谱中的 Has_circ_0055625 通过海绵吸附 miR-106b-5p 促进结肠癌细胞生长。
Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p.
机构信息
Department of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
出版信息
J Cell Biochem. 2019 Mar;120(3):3027-3037. doi: 10.1002/jcb.27355. Epub 2018 Dec 5.
Circular RNAs (circRNA) are endogenous noncoding RNAs and play important roles in cancer; however, the roles of circRNAs in colon cancer are far from clear. The circRNA expression profile in colon cancer tissues was analyzed by microarray. The data from microarray showed that there were 198 upregulated and 136 downregulated circRNAs in colon cancer tissues. Among the top 10 upregulated circRNAs, hsa_circ_0055625 (circ_0055625) was confirmed to be significantly upregulated in colon cancer tissues. Further analysis demonstrated that circ_0055625 might get involved in the pathogenesis of colon cancer by functioning as miRNA sponges and performed bioinformatics analysis of the predicted circ_0055625/miR-106b-5p (miR-106b)/ITGB8 network. Moreover, we found that circ_0055625 expression was associated with pathological TNM stage and metastasis. These data indicated that circ_0055625/miR-106b/ITGB8 played a role in promoting tumor growth and metastasis, which suggested that circ_0055625 was a potential biomarker of colon cancer.
环状 RNA（circRNA）是内源性的非编码 RNA，在癌症中发挥重要作用；然而，circRNA 在结肠癌中的作用尚不清楚。通过微阵列分析结肠癌组织中的 circRNA 表达谱。微阵列数据显示，结肠癌组织中有 198 个上调的和 136 个下调的 circRNA。在 top10 上调的 circRNA 中，hsa_circ_0055625（circ_0055625）被证实明显上调。进一步分析表明，circ_0055625 可能通过作为 miRNA 海绵参与结肠癌的发病机制，并对预测的 circ_0055625/miR-106b-5p（miR-106b）/ITGB8 网络进行了生物信息学分析。此外，我们发现 circ_0055625 的表达与病理 TNM 分期和转移有关。这些数据表明，circ_0055625/miR-106b/ITGB8 在促进肿瘤生长和转移中发挥作用，这表明 circ_0055625 是结肠癌的一个潜在的生物标志物。
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