Kanada S A, Kolling W M, Hindin B I
Am J Hosp Pharm. 1978 Mar;35(3):330-6.
A case of aspirin hepatotoxicity in a 46-year-old male with rheumatoid arthritis is discussed, and this adverse reaction is reviewed. The patient was started on 900 mg aspirin four times daily; five days later the dose was increased to 1200 mg four times daily. After six days' therapy of 4.8 g aspirin daily, the serum salicylate level rose to 25 mg/100 ml and liver enzymes became elevated. Aspirin was discontinued and ibuprofen, 600 mg four times daily, begun. Eight days after cessation of aspirin therapy, the patient's liver enzyme values returned to normal. Previous case reports and studies of aspirin-induced hepatotoxicity are reviewed. It is concluded that aspirin-induced hepatotoxicity occurs much more frequently in patients with rheumatoid arthritis and other connective tissue disorders than previously recognized.
讨论了一名46岁类风湿性关节炎男性患者的阿司匹林肝毒性病例，并对这种不良反应进行了回顾。患者开始每日4次服用900毫克阿司匹林；5天后剂量增加至每日4次1200毫克。在每日服用4.8克阿司匹林进行6天治疗后，血清水杨酸水平升至25毫克/100毫升，肝酶升高。停用阿司匹林，开始每日4次服用600毫克布洛芬。阿司匹林治疗停止8天后，患者的肝酶值恢复正常。回顾了先前关于阿司匹林诱导肝毒性的病例报告和研究。得出的结论是，阿司匹林诱导的肝毒性在类风湿性关节炎和其他结缔组织疾病患者中发生的频率比以前认识到的要高得多。
