Keramida Georgia, Peters A Michael
Clinical Imaging Sciences Centre.
Royal Brompton and Harefield Foundation Trust, London, UK.
Nucl Med Commun. 2019 Jan;40(1):3-7. doi: 10.1097/MNM.0000000000000935.
To compare weight, lean body mass and body surface area for calculation of standardised uptake value (SUV) in fluorine-18-fluorodeoxyglucose PET/computed tomography, taking sex into account.
This was a retrospective study of 161 (97 men) patients. Maximum standardised uptake value (SUVmax) and mean standardised uptake value (SUVmean) were obtained from a 3-cm region of interest over the right lobe of the liver and scaled to weight, scaled to lean body mass (SUL) and scaled to body surface area (SUA). Mean hepatic computed tomography density was used to adjust SUVmean for hepatic fat (SUVFA). Hepatic SUV indices were divided by SUV from left ventricular cavity, thereby, eliminating whole body metric, to obtain a surrogate of blood fluorine-18-fluorodeoxyglucose clearance into liver, and multiplied by blood glucose to give a surrogate of hepatic glucose uptake rate (mSUV).
SULmax, SUAmax and all scaled to weight indices correlated strongly with weight. SULmean, SULFA, SUAmean and SUAFA, however, correlated weakly or not at all with weight, nor with their corresponding whole body metric in men or women, but correlated strongly when the sexes were combined into one group. This was the result of sex differences in SUL (greater in men) and SUA (greater in women). There was, however, no sex difference in mSUV.
Weight is unsuitable for calculating SUV. SUL and SUA are also inappropriate as maxima but appropriate as mean and fat-adjusted values. However, SUL is recommended for both sexes because SUA is influenced by both body fat and weight. Sex differences in SUL and SUA give rise to misleading correlations when sexes are combined into one group.
在考虑性别的情况下，比较体重、去脂体重和体表面积用于计算18F-氟脱氧葡萄糖PET/计算机断层扫描中的标准化摄取值（SUV）。
这是一项对161例患者（97例男性）的回顾性研究。从肝脏右叶的一个3厘米感兴趣区域获得最大标准化摄取值（SUVmax）和平均标准化摄取值（SUVmean），并将其按体重进行标化、按去脂体重进行标化（SUL）以及按体表面积进行标化（SUA）。使用肝脏计算机断层扫描平均密度对SUVmean进行肝脏脂肪校正（SUVFA）。将肝脏SUV指数除以左心室腔的SUV，从而消除全身指标，以获得肝脏对血液中18F-氟脱氧葡萄糖清除率的替代指标，并乘以血糖以得到肝脏葡萄糖摄取率的替代指标（mSUV）。
SULmax、SUAmax以及所有按体重标化的指标与体重密切相关。然而，SULmean、SULFA、SUAmean和SUAFA与体重的相关性较弱或根本不相关，在男性或女性中与相应的全身指标也不相关，但当将两性合并为一组时相关性很强。这是由于SUL（男性中更大）和SUA（女性中更大）存在性别差异。然而，mSUV没有性别差异。
体重不适用于计算SUV。SUL和SUA作为最大值也不合适，但作为平均值和脂肪校正值是合适的。然而，推荐使用SUL，因为SUA受体脂和体重两者影响。当将两性合并为一组时，SUL和SUA的性别差异会导致产生误导性的相关性。
