Jordán J, Blasco M C, Juste M G, Pérez González J M
Departamento de Pediatría y Puericultura, Facultad de Medicina, Hospital Clínico Universitario de Zaragoza.
An Esp Pediatr. 1988 May;28(5):417-21.
This report analyses erythrocyte insulin binding and specific erythrocyte insulin receptors in the neonatal period. Authors have studied thirty normal newborns who had an adequate weight for their gestational age and another fifteen who were asymmetric intrauterine retarded growth. Cord blood samples were collected and insulin binding, insulin receptors, blood glucose concentration, serum immunoreactive insulin, serum C-peptide concentration and molar ratio of C-peptide to insulin were determined. Insulin and C-peptide sera concentrations suggest that basal insulin secretion in small for data newborns is similar to term infants. Significantly minor affinity constant (p = 0.05) and significantly major dissociation constant (p = 0.05) in small for date infants versus newborns adequately weighted for their gestational age, justify the increased sensitivity to insulin as it happens in other states of chronic undernutrition. In small for date infants, number of sites per cell correlates negatively (r = -0.57, p less than 0.05) with birth weight. Up regulation mechanism that modulates receptors concentration could explain this phenomenon.
本报告分析了新生儿期红细胞胰岛素结合情况及特异性红细胞胰岛素受体。作者研究了30名出生体重与其孕周相符的正常新生儿，以及另外15名宫内生长不对称迟缓的新生儿。采集脐血样本，测定胰岛素结合、胰岛素受体、血糖浓度、血清免疫反应性胰岛素、血清C肽浓度以及C肽与胰岛素的摩尔比。胰岛素和C肽血清浓度表明，小于胎龄新生儿的基础胰岛素分泌与足月儿相似。小于胎龄儿与出生体重与其孕周相符的新生儿相比，亲和力常数显著较小（p = 0.05），解离常数显著较大（p = 0.05），这证明了其对胰岛素的敏感性增加，如同在其他慢性营养不良状态下一样。在小于胎龄儿中，每个细胞的位点数量与出生体重呈负相关（r = -0.57，p < 0.05）。调节受体浓度的上调机制可以解释这一现象。
