Setia Sajita, Sridhar M G, Koner B C, Bobby Zachariah, Bhat Vishnu, Chaturvedula Lata
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry - 605 006, India.
Clin Chim Acta. 2007 Feb;376(1-2):37-40. doi: 10.1016/j.cca.2006.07.007. Epub 2006 Jul 14.
Thyroid hormones are necessary for normal brain development. We studied thyroid hormone profile and insulin sensitivity in intrauterine growth retarded (IUGR) newborns to find correlation between insulin sensitivity and thyroid status in IUGR newborns.
Fifty IUGR and fifty healthy control infants were studied at birth. Cord blood was collected for determination of T(3), T(4), TSH, glucose and insulin levels.
IUGR newborns had significantly lower insulin, mean+/-S.D., 5.25+/-2.81 vs. 11.02+/-1.85microU/ml, but significantly higher insulin sensitivity measured as glucose to insulin ratio (G/I), 9.80+/-2.91 vs. 6.93+/-1.08 compared to healthy newborns. TSH was also significantly higher 6.0+/-2.70 vs. 2.99+/-1.05microU/ml with significantly lower T(4), 8.65+/-1.95 vs. 9.77+/-2.18microg/dl, but similar T(3) levels, 100.8+/-24.36 vs. 101.45+/-23.45ng/dl. On stepwise linear regression analysis in IUGR infants, insulin sensitivity was found to have a significant negative association with T(4) and significant positive association with TSH.
Thyroid hormones may play a role in increased insulin sensitivity at birth in IUGR.
甲状腺激素对正常脑发育至关重要。我们研究了宫内生长受限（IUGR）新生儿的甲状腺激素水平和胰岛素敏感性，以探寻IUGR新生儿胰岛素敏感性与甲状腺状态之间的相关性。
对50例IUGR新生儿和50例健康对照婴儿在出生时进行研究。采集脐血以测定T(3)、T(4)、促甲状腺激素（TSH）、葡萄糖和胰岛素水平。
IUGR新生儿的胰岛素水平显著较低，均值±标准差为5.25±2.81 vs. 11.02±1.85微单位/毫升，但以葡萄糖与胰岛素比值（G/I）衡量的胰岛素敏感性显著较高，分别为9.80±2.91 vs. 6.93±1.08，与健康新生儿相比。TSH也显著较高，为6.0±2.70 vs. 2.99±1.05微单位/毫升，T(4)显著较低，为8.65±1.95 vs. 9.77±2.18微克/分升，但T(3)水平相似，为100.8±24.36 vs. 101.45±23.45纳克/分升。在IUGR婴儿的逐步线性回归分析中，发现胰岛素敏感性与T(4)呈显著负相关，与TSH呈显著正相关。
甲状腺激素可能在IUGR新生儿出生时胰岛素敏感性增加中起作用。
