Cresser Sam, Maddock Lachlan, Smart Philip
Eastern Clinical School, Eastern Health, Melbourne Australia.
Department of Vascular Surgery, Eastern Health, Melbourne Australia.
Int J Surg Case Rep. 2019;54:51-54. doi: 10.1016/j.ijscr.2018.10.083. Epub 2018 Nov 22.
There is a known association between Clostridium Septicum, mycotic aneurysm and colon neoplasm.
We report the case of a 90 year old female admitted with abdominal pain to the general surgery unit. Admission CT scan demonstrated a thick walled caecum and pericaecal inflammation suspicious for a perforated carcinoma. This was subsequently confirmed at colonoscopy with biopsy demonstrating a poorly differentiated adenocarcinoma. A laparoscopic right hemicolectomy was completed the following week after perioperative workup and intravenous antibiotic therapy. On the 9th postoperative day, fever and rising inflammatory markers prompted repeat abdominal CT scan which demonstrated a mycotic aneurysm of the upper abdominal aorta. After discussion with the vascular surgery and infectious diseases team, along the patient and family, the decision was made to palliate. The patient died at home from presumed spontaneous rupture two weeks after discharge.
Mycotic aneurysm in colonic malignancy is a rare and often lethal complication. C. Septicum is causative in over 70% of cases with concomitant colonic malignancy.
Mycotic aneurysm should be considered in any deteriorating patient with concomitant colonic malignancy.
已知败血梭菌、霉菌性动脉瘤与结肠肿瘤之间存在关联。
我们报告一例90岁女性因腹痛入住普通外科病房。入院时的CT扫描显示盲肠壁增厚及盲肠周围炎症,怀疑为穿孔性癌。随后结肠镜检查及活检证实为低分化腺癌。经过围手术期检查和静脉抗生素治疗后,于下周完成了腹腔镜右半结肠切除术。术后第9天,发热及炎症指标升高促使再次进行腹部CT扫描,结果显示腹主动脉上段有霉菌性动脉瘤。在与血管外科和感染病团队、患者及其家属讨论后,决定采取姑息治疗。患者出院两周后在家中因推测的自发性破裂死亡。
结肠恶性肿瘤中的霉菌性动脉瘤是一种罕见且往往致命的并发症。在超过70%伴有结肠恶性肿瘤的病例中,败血梭菌是病因。
对于任何伴有结肠恶性肿瘤且病情恶化的患者,都应考虑霉菌性动脉瘤的可能。