Lundy J, Chen J, Wang P, Fromowitz F, Schuss A, Lynch S, Brugge J, Viola M V
State University of New York, Stony Brook 11794.
Anticancer Res. 1988 Sep-Oct;8(5A):1005-13.
Cell dysplasia in polyps and in ulcerative colitis are thought to be the pre-cancerous lesion leading to invasive colon cancer. Many polyps and dysplastic lesions in ulcerative colitis have phenotypic changes (blood group antigen, cytokeratins, CEA, TAG-72.3 antigen expression) and genetic changes (c-K-ras mutation, enhanced c-myc expression and pp60c-src activity) which are characteristic of invasive cancers. Thus, these early pre-cancerous lesions may be a late stage in the genetic evolution of colon cancer.
息肉和溃疡性结肠炎中的细胞发育异常被认为是导致浸润性结肠癌的癌前病变。溃疡性结肠炎中的许多息肉和发育异常病变具有表型变化（血型抗原、细胞角蛋白、癌胚抗原、TAG-72.3抗原表达）和基因变化（c-K-ras突变、c-myc表达增强和pp60c-src活性增强），这些都是浸润性癌症的特征。因此，这些早期癌前病变可能是结肠癌基因进化的晚期阶段。
