Ciclitira P J, Macartney J C, Evan G
J Pathol. 1987 Apr;151(4):293-6. doi: 10.1002/path.1711510409.
A monoclonal antibody 1-6E10 against the protein product p62c-myc of the c-myc oncogene was used to assess, by immunohistology, a variety of non-neoplastic and preneoplastic disorders of gastric and colonic mucosa. There were low levels of expression of the c-myc oncogenic product in normal gastric and colonic tissue. In gastric mucosa, increased expression was observed with inflammatory, metaplastic and dysplastic histological appearances. In the normal colon low levels of expression were observed, but there was increased expression in inflammatory disorders including Crohn's disease and ulcerative colitis. There was also increased expression in colonic dysplasia associated with ulcerative colitis. The oncogene product was localized in the cytoplasm, nuclei and Golgi apparatus. C-myc 1-6E10 may therefore be used as a marker to identify the cellular proliferative response in gastric and colonic mucosa that is associated with inflammation as well as potentially neoplastic hyperproliferative states.
一种针对c-myc癌基因蛋白产物p62c-myc的单克隆抗体1-6E10，被用于通过免疫组织学评估胃和结肠黏膜的多种非肿瘤性和肿瘤前疾病。在正常胃和结肠组织中，c-myc致癌产物的表达水平较低。在胃黏膜中，随着炎症、化生和发育异常的组织学表现，观察到表达增加。在正常结肠中观察到低水平表达，但在包括克罗恩病和溃疡性结肠炎在内的炎症性疾病中表达增加。在与溃疡性结肠炎相关的结肠发育异常中也观察到表达增加。癌基因产物定位于细胞质、细胞核和高尔基体。因此，c-myc 1-6E10可用作一种标志物，以识别胃和结肠黏膜中与炎症以及潜在的肿瘤性过度增殖状态相关的细胞增殖反应。
