Tuan Mohamood Nur Fattima' Al-Zahara', Zainuddin Norhazlin, Ahmad Ayob Mansor, Tan Sheau Wei
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Laboratory of Vaccine and Immunotherapeutic, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Chem Cent J. 2018 Dec 6;12(1):133. doi: 10.1186/s13065-018-0500-8.
In this study, sago starch was modified in order to enhance its physicochemical properties. Carboxymethylation was used to introduce a carboxymethyl group into a starch compound. The carboxymethyl sago starch (CMSS) was used to prepare smart hydrogel by adding acetic acid into the CMSS powder as the crosslinking agent. The degree of substitution of the CMSS obtained was 0.6410. The optimization was based on the gel content and degree of swelling of the hydrogel. In this research, four parameters were studied in order to optimize the formation of CMSS-acid hydrogel. The parameters were; CMSS concentration, acetic acid concentration, reaction time and reaction temperature. From the data analyzed, 76.69% of optimum gel content was obtained with 33.77 g/g of degree of swelling. Other than that, the swelling properties of CMSS-acid hydrogel in different media such as salt solution, different pH of phosphate buffer saline solution as well as acidic and alkaline solution were also investigated. The results showed that the CMSS-acid hydrogel swelled in both alkaline and salt solution, while in acidic or low pH solution, it tended to shrink and deswell. The production of the hydrogel as a smart material offers a lot of auspicious benefits in the future especially related to swelling behaviour and properties of the hydrogel in different types of media.
在本研究中，对西米淀粉进行改性以增强其物理化学性质。采用羧甲基化法将羧甲基引入淀粉化合物中。通过向羧甲基西米淀粉（CMSS）粉末中加入乙酸作为交联剂来制备智能水凝胶。所获得的CMSS的取代度为0.6410。优化基于水凝胶的凝胶含量和溶胀度。在本研究中，研究了四个参数以优化CMSS-酸水凝胶的形成。这些参数为：CMSS浓度、乙酸浓度、反应时间和反应温度。根据分析数据，获得了76.69%的最佳凝胶含量，溶胀度为33.77 g/g。除此之外，还研究了CMSS-酸水凝胶在不同介质（如盐溶液、不同pH值的磷酸盐缓冲盐水溶液以及酸性和碱性溶液）中的溶胀特性。结果表明，CMSS-酸水凝胶在碱性和盐溶液中均会溶胀，而在酸性或低pH值溶液中则倾向于收缩和消肿。作为一种智能材料的水凝胶的生产在未来具有许多有利的益处，特别是与水凝胶在不同类型介质中的溶胀行为和特性有关。
