内皮素抑制离体大鼠肾小球释放肾素。

Endothelin inhibits renin release from isolated rat glomeruli.

作者信息

Rakugi H, Nakamaru M, Saito H, Higaki J, Ogihara T

机构信息

Department of Medicine and Geriatrics, Osaka University Medical School, Japan.

出版信息

Biochem Biophys Res Commun. 1988 Sep 30;155(3):1244-7. doi: 10.1016/s0006-291x(88)81273-7.

DOI:10.1016/s0006-291x(88)81273-7

PMID:3052444

Abstract

The effect of endothelin on renin release from isolated rat glomeruli was examined. Endothelin inhibited basal renin release in a dose-dependent manner with an IC50 of 1.0 x 10(-9) M. Endothelin also inhibited renin release stimulated by isoproterenol (10(-5) M). Nifedipine (10(-5) M), a calcium channel blocker, induced an increase in renin release. Endothelin did not affect this nifedipine-induced renin release. These results suggest that endothelin inhibits renin release via a calcium entry mechanism and increases intracellular calcium.

摘要

研究了内皮素对离体大鼠肾小球肾素释放的影响。内皮素以剂量依赖性方式抑制基础肾素释放，IC50为1.0×10（-9）M。内皮素还抑制异丙肾上腺素（10（-5）M）刺激的肾素释放。钙通道阻滞剂硝苯地平（10（-5）M）可诱导肾素释放增加。内皮素不影响硝苯地平诱导的肾素释放。这些结果表明，内皮素通过钙内流机制抑制肾素释放并增加细胞内钙。