Waller P C, Ramsay L E
University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, UK.
Biomed Pharmacother. 1988;42(3):207-11.
Non-gouty arthritis is quite common in hypertensive populations and there have been suggestions that drugs used to treat hypertension may be the cause. This possibility has been investigated in a case-control study. We identified 127 hypertensive patients with arthritis other than gout and matched them for age and sex to 254 hypertensive controls who did not have arthritis. Use of antihypertensive drugs was similar in cases and controls for all patients, and for those with undiagnosed arthritis. There was no significant excess use of any type of antihypertensive drug by cases with arthritis. These findings do not support the hypothesis that drug treatment for hypertension commonly causes arthritis. It is more likely that hypertension and arthritis occur together frequently because non-steroidal anti-inflammatory drugs raise blood pressure, and because both problems are common in middle-age.
非痛风性关节炎在高血压人群中相当常见，有人认为用于治疗高血压的药物可能是病因。一项病例对照研究对这种可能性进行了调查。我们确定了127名患有除痛风以外关节炎的高血压患者，并将他们按年龄和性别与254名没有关节炎的高血压对照者进行匹配。所有患者以及那些未确诊关节炎的患者中，病例组和对照组使用抗高血压药物的情况相似。患有关节炎的病例组并未显著过量使用任何类型的抗高血压药物。这些发现不支持高血压药物治疗通常会导致关节炎这一假设。更有可能的是，高血压和关节炎经常同时出现，因为非甾体抗炎药会升高血压，而且这两个问题在中年人群中都很常见。
