Modebe O, Eze C J
Department of Medicine, University of Nigeria Teaching Hospital, Enugu.
West Afr J Med. 1993 Jan-Mar;12(1):73-7.
Three cases, in which the deterioration of blood pressure control was associated with the onset of therapy with nonsteroidal anti-inflammatory drugs (NSAIDS), are reported. It is suggested that this effect of the NSAIDs could possibly have resulted from the inhibition of the biosynthesis of the prostaglandins, some of which have vasodilatory or natriuretic properties. This interaction, hitherto unreported from our environment and therefore not commonly recognised, is of relevance in the drug treatment of hypertension since the widely used NSAIDs have the potential to impair the effectiveness of several antihypertensive drugs. It should be taken cognizance of when using both antihypertensive drugs and NSAIDs in any hypertensive patient.
报告了3例血压控制恶化与非甾体抗炎药（NSAIDs）治疗开始相关的病例。提示NSAIDs的这种作用可能是由于抑制了前列腺素的生物合成，其中一些前列腺素具有血管舒张或利钠特性。这种相互作用在我们的环境中迄今尚未报道，因此未被普遍认识，在高血压药物治疗中具有相关性，因为广泛使用的NSAIDs有可能损害几种抗高血压药物的有效性。在任何高血压患者中同时使用抗高血压药物和NSAIDs时都应予以注意。
