Kaushik A, Matthes T, Dighiero G
Unite Immunohaematologie et Immunopathologie, Institut Pasteur, Paris, France.
Blood Cells. 1988;14(1):161-74.
Natural autoantibodies (NAAbs) are an important constituent of circulating immunoglobins. Some demonstrate polyspecific reactivity and high idiotypic connectivity. For example, they are reactive with DNA and cytoskeleton protein; others exhibit restricted binding specificity. Among several hypotheses, we have explored the possibility that NAAbs constitute a physiologic system in the organism that participates in the elimination of dead tissues and cellular debris by opsonization and phagocytosis.
天然自身抗体（NAAbs）是循环免疫球蛋白的重要组成部分。一些天然自身抗体表现出多特异性反应性和高度独特型连接性。例如，它们可与DNA和细胞骨架蛋白发生反应；其他天然自身抗体则表现出受限的结合特异性。在多种假说中，我们探讨了天然自身抗体构成机体生理系统的可能性，该系统通过调理作用和吞噬作用参与清除死亡组织和细胞碎片。
