Kay M M, Sorensen K, Wong P, Bolton P
Mol Cell Biochem. 1982 Nov 26;49(2):65-85. doi: 10.1007/BF00242486.
Normal human serum contains autoantibodies to a wide range of cellular and serum proteins. IgG autoantibodies to cell membrane proteins spectrin, syndein (Band 2.1), Band 3 degradation products, and the senescent cell antigen are among them. Physiologic autoantibodies to the senescent cell antigen, a approximately 62 000 dalton glycopeptide derived from Band 3, initiate removal of senescent, damaged, and stored cells in vivo. The senescent cell antigen is one of the two Band 3 degradation products (Mr approximately 66 000 and 62 000) observed in freshly prepared ghosts. Since the senescent cell antigen is observed on red cells aged in situ, data suggest that Band 3 undergoes proteolysis in situ. IgG eluted from blood stored for transfusion binds to the senescent cell antigen. The amount of IgG on red cells increases during storage suggesting accumulation of the senescent cell antigen. Autoantibodies to other cell and serum proteins are discussed as possible regulators of homeostasis. The effect of age on physiologic autoantibodies is reviewed.
正常人血清中含有针对多种细胞和血清蛋白的自身抗体。其中包括针对细胞膜蛋白血影蛋白、联合素（带2.1）、带3降解产物以及衰老细胞抗原的IgG自身抗体。针对衰老细胞抗原的生理性自身抗体是一种源自带3的约62000道尔顿的糖肽，可在体内启动对衰老、受损和储存细胞的清除。衰老细胞抗原是在新鲜制备的血影中观察到的两种带3降解产物（分子量约为66000和62000）之一。由于在原位老化的红细胞上观察到衰老细胞抗原，数据表明带3在原位发生蛋白水解。从用于输血储存的血液中洗脱的IgG与衰老细胞抗原结合。红细胞上IgG的量在储存期间增加，表明衰老细胞抗原的积累。针对其他细胞和血清蛋白的自身抗体被讨论为内环境稳定的可能调节因子。综述了年龄对生理性自身抗体的影响。
