妊娠期糖尿病患者体内的循环前神经降压素

Circulating Pro-Neurotensin in gestational diabetes mellitus.

作者信息

Tönjes A, Kralisch S, Hoffmann A, Schleinitz D, Kratzsch J, Blüher M, Stumvoll M, Kovacs P, Fasshauer M, Ebert T

机构信息

University of Leipzig, Department of Endocrinology and Nephrology, 04103, Leipzig, Germany.

University of Leipzig, Department of Endocrinology and Nephrology, 04103, Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103, Leipzig, Germany.

出版信息

Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):23-29. doi: 10.1016/j.numecd.2018.09.011. Epub 2018 Oct 20.

DOI:10.1016/j.numecd.2018.09.011

PMID:30527352

Abstract

BACKGROUND AND AIMS

Pro-Neurotensin (NT), a stable surrogate parameter of NT, has recently been introduced as a peptide predicting the development of obesity, diabetes mellitus, cardiovascular diseases, and cardiovascular mortality. However, regulation of Pro-NT in gestational diabetes mellitus (GDM) remains uninvestigated.

METHODS AND RESULTS

Pro-NT was quantified in 74 women with GDM, 74 healthy, gestational age-matched, pregnant controls, as well as in a second cohort comprising of 74 healthy, non-pregnant control women, using a chemiluminometric sandwich immunoassay. Pro-NT was correlated to measures of obesity, hypertension, glucose and lipid metabolism, renal function, and inflammation. Mean ± standard deviation of circulating Pro-NT levels were not significantly different in women with GDM (100.2 ± 75.7 pmol/l) as compared to healthy, pregnant controls (103.2 ± 37.4 pmol/l) and healthy, non-pregnant female controls (105.9 ± 38.9 pmol/l) (p = 0.661). Homeostasis model assessment of insulin resistance (HOMA-IR) and creatinine positively correlated with serum Pro-NT in multivariate regression analysis. In contrast, free fatty acids (FFA) were inversely correlated with circulating Pro-NT. Results sustained adjustment for pregnancy status.

CONCLUSIONS

Circulating Pro-NT is not independently associated with GDM, but is with HOMA-IR, creatinine, and FFA even after adjustment for pregnancy status.

摘要

背景与目的

前神经降压素（Pro-NT）作为神经降压素（NT）的一个稳定替代参数，最近被引入作为一种可预测肥胖、糖尿病、心血管疾病及心血管疾病死亡率发生发展的肽类物质。然而，妊娠期糖尿病（GDM）中Pro-NT的调节机制仍未得到研究。

方法与结果

采用化学发光夹心免疫分析法，对74例患有GDM的女性、74例健康的、孕周匹配的孕妇对照组以及另一组由74例健康非孕女性对照组进行Pro-NT定量检测。将Pro-NT与肥胖、高血压、糖脂代谢、肾功能及炎症指标进行相关性分析。与健康孕妇对照组（103.2±37.4 pmol/l）和健康非孕女性对照组（105.9±38.9 pmol/l）相比，GDM女性循环Pro-NT水平的均值±标准差无显著差异（100.2±75.7 pmol/l）（p = 0.661）。在多因素回归分析中，胰岛素抵抗稳态模型评估（HOMA-IR）和肌酐与血清Pro-NT呈正相关。相反，游离脂肪酸（FFA）与循环Pro-NT呈负相关。即使对妊娠状态进行校正，结果依然成立。