6p+ and 9q- in two chromosomally distinct clones occurring in a case of myelodysplastic syndrome evolving to acute nonlymphocytic leukemia.
作者信息
Ringressi A, Mecucci C, Grossi A, Bernabei P A, Ferrini P R, Van den Berghe H
机构信息
Department of Hematology, University of Florence, Italy.
出版信息
Cancer Genet Cytogenet. 1988 Oct 15;35(2):213-21. doi: 10.1016/0165-4608(88)90243-9.
PMID:3052797
Abstract
Different and unrelated chromosome changes were found to occur in a patient with a myelodysplastic syndrome with rapid evolution to acute nonlymphocytic leukemia. A 6p anomaly was found during the chronic phase and a del(9q) characterized the cells in the leukemic phase. Deletions with a breakpoint in 9q31 appeared to be associated with more aggressive disease.
摘要
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