不平衡6p易位作为继发性急性非淋巴细胞白血病的原发性核型异常
Unbalanced 6p translocation as primary karyotypic anomaly in secondary acute nonlymphocytic leukemia.
作者信息
Mancini M, Mecucci C, Cedrone M, Rondinelli M B, Aloe-Spiriti M A, Alimena G
机构信息
Hematology, Department of Human Biopathology, University of Rome La Sapienza, Italy.
出版信息
Cancer Genet Cytogenet. 1992 May;60(1):93-5. doi: 10.1016/0165-4608(92)90242-z.
PMID:1591714
Abstract
A case of acute nonlymphocytic leukemia after radiochemotherapy for Hodgkin's disease, with a rearrangement of 6p23 region, is described. This chromosome change, which has been previously reported in secondary leukemias or myelodysplastic syndromes, was an isolated karyotypic anomaly in our case, which strongly supports the nonrandom involvement of chromosome 6p in induced leukemias.
摘要
本文描述了1例霍奇金病放化疗后发生的急性非淋巴细胞白血病，伴有6p23区域重排。这种染色体改变先前已在继发性白血病或骨髓增生异常综合征中报道过，在我们的病例中是一种孤立的核型异常，这有力地支持了6号染色体短臂在诱导白血病中存在非随机受累情况。
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