Famaey J P
Department of Rheumatology, Hôpital Universitaire Saint-Pierre, University of Brussels, Belgium.
Clin Exp Rheumatol. 1988 Jul-Sep;6(3):305-17.
Colchicine is the most specific treatment in acute gouty attacks. In several European countries, oral colchicine is still used for routine treatment of acute gout. Its selectivity is used as a diagnostic tool. It is also active in the treatment of acute crises of chondrocalcinosis and more occasionally of other arthritic crises (e.g. sarcoidosis). Colchicine appears to be the necessary adjuvant prophylactic drug when starting a hypouricemic treatment with uricosuric or uricolytic drugs for avoiding acute gouty crisis due to sudden mobilisation of the uric acid pool. Besides gout, colchicine is the drug of choice for treating familial mediterranean fever. It appears to be helpful in the treatment of Behçet's disease. It seems also useful for treating fibrosing conditions such as liver cirrhosis and scleroderma. As an adjuvant therapy, it helps treating dermatological disorders which are associated with leucocyte migration as an essential pathogenic factor (e.g. psoriasis, dermatitis herpetiformis, necrotising vasculitis ...). It has been advocated as an adjuvant therapy in malignant diseases as a support in radiotherapy and as an useful drug in various other diseases where it has been tried occasionally (e.g. Paget's disease of the bone, idiopathic thrombocytopenic purpura, disc syndrome). This very old drug remains a modern therapeutic agent.
秋水仙碱是急性痛风发作时最具特异性的治疗药物。在几个欧洲国家，口服秋水仙碱仍用于急性痛风的常规治疗。其选择性被用作一种诊断工具。它在治疗软骨钙质沉着症的急性发作以及较少见的其他关节炎发作（如结节病）时也有作用。当开始使用促尿酸排泄药或尿酸分解药进行降尿酸治疗以避免因尿酸池突然动员而引发急性痛风发作时，秋水仙碱似乎是必要的辅助预防药物。除痛风外，秋水仙碱是治疗家族性地中海热的首选药物。它在治疗白塞病方面似乎也有帮助。它似乎对治疗诸如肝硬化和硬皮病等纤维化疾病也有用。作为辅助治疗，它有助于治疗以白细胞迁移为重要致病因素的皮肤病（如银屑病、疱疹样皮炎、坏死性血管炎……）。它已被提倡作为恶性疾病的辅助治疗，用于放疗支持，并且在偶尔尝试过的各种其他疾病（如骨佩吉特病、特发性血小板减少性紫癜、椎间盘综合征）中也是一种有用的药物。这种非常古老的药物仍然是一种现代治疗剂。
