School of Marine Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, China.
Phytochemistry. 2019 Feb;158:120-125. doi: 10.1016/j.phytochem.2018.11.017. Epub 2018 Dec 5.
Two undescribed prenylbenzaldehyde derivatives, cristaldehydes A and B, and an undescribed quinone derivative, cristaquinone A, along with seven known compounds were isolated from the fungus Eurotium cristatum. The structures of undescribed compounds were determined by spectroscopic analysis including NMR, HR-ESIMS, and single-crystal X-ray diffraction. This is the first report of identification of a dibenzannulated 6,6-spiroketal derivative, cristaldehyde B, in a natural product. Cytotoxic and anti-inflammatory activities of all compounds were evaluated. Cristaldehyde A and cristaquinone A along with five known compounds showed significant anti-inflammatory activities with IC values in the range from 0.37 to 14.50 μM.
从真菌青霉属（Eurotium cristatum）中分离得到两个未被描述的prenylbenzaldehyde 衍生物，cristaldehydes A 和 B，以及一个未被描述的醌衍生物 cristaquinone A，同时分离得到了七个已知化合物。通过包括 NMR、HR-ESIMS 和单晶 X 射线衍射在内的光谱分析确定了未知化合物的结构。这是首次在天然产物中鉴定出二苯并稠合 6,6-螺缩酮衍生物 cristaldehyde B。所有化合物的细胞毒性和抗炎活性都进行了评估。cristaldehydes A 和 cristaquinone A 以及五个已知化合物表现出显著的抗炎活性，IC 值范围为 0.37 至 14.50 μM。
