基于 LC-MS 的中国沉香（Aquilaria sinensis）中抗炎 2-(2-苯乙基)色酮二聚体的分离。
LC-MS-guided isolation of anti-inflammatory 2-(2-phenylethyl)chromone dimers from Chinese agarwood (Aquilaria sinensis).
机构信息
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
出版信息
Phytochemistry. 2019 Feb;158:46-55. doi: 10.1016/j.phytochem.2018.11.003. Epub 2018 Nov 17.
Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The isolated compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC values in the range 0.6-37.1 μM.
从中国沉香（Aquilaria sinensis）中通过 LC-MS 引导的分段程序分离出十五种以前未描述的 2-(2-苯乙基)色酮二聚体，以及两种已知类似物。基于光谱和光谱数据（1D 和 2D NMR、IR 和 HRESIMS）阐明了它们的结构。分离出的化合物对脂多糖刺激的 RAW264.7 细胞中一氧化氮的产生具有显著的抑制作用，IC 值范围为 0.6-37.1 μM。
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