Rajatanavin N, Scharf M J, Bernhard J D
Division of Dermatology, University of Massachusetts Medical Center, Worcester 01655.
Compr Ther. 1988 Oct;14(10):11-8.
Phototherapy and photochemotherapy have been shown to be effective treatments in a number of cutaneous disorders, but they are not without risk. PUVA has revolutionized the treatment of psoriasis and stimulated major improvements in the administration of UVB therapy. Successful treatment depends on careful patient selection and evaluation. Accurate dosimetry and close supervision are necessary to avoid complications. Regular and careful follow-up, both during and after therapy, can help to identify and treat long-term side effects such as non-melanoma skin cancers. In order to achieve the necessary balance between benefits and risks with these valuable forms of therapy, patients should be referred to dermatologists with special training.
光疗和光化学疗法已被证明在多种皮肤疾病的治疗中有效，但并非毫无风险。补骨脂素加长波紫外线光化学疗法（PUVA）彻底改变了银屑病的治疗方法，并推动了中波紫外线（UVB）疗法给药方式的重大改进。成功的治疗取决于对患者的仔细选择和评估。准确的剂量测定和密切监测对于避免并发症是必要的。在治疗期间和治疗后进行定期且仔细的随访，有助于识别和治疗诸如非黑素瘤皮肤癌等长期副作用。为了在这些有价值的治疗方式中实现收益与风险之间的必要平衡，应将患者转诊至经过专门培训的皮肤科医生处。
