Toscano Eliana Cristina de Brito, Lessa João Marcelo Korcsik, Gonçalves Ana Paula, Rocha Natalia Pessoa, Giannetti Alexandre Varella, de Oliveira Guilherme Nogueira, Rachid Milene Alvarenga, Vieira Érica Leandro Marciano, Teixeira Antônio Lúcio
Laboratório Interdisciplinar de Investigação Médica, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Laboratório Interdisciplinar de Investigação Médica, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Epilepsy Behav. 2019 Jan;90:137-141. doi: 10.1016/j.yebeh.2018.11.023. Epub 2018 Dec 7.
A persistent low-grade inflammatory state has been described in patients with temporal lobe epilepsy (TLE) in the interictal period. Adipokines are cytokines produced by the adipose tissue that can influence inflammatory response. The purpose of this study was to evaluate the plasma levels of adipokines in patients with TLE in comparison with controls. In addition, we sought to investigate whether the levels of adipokines were associated with clinical parameters in TLE.
Forty patients with TLE and 40 controls were enrolled in this study. All participants were subjected to clinical assessment that included the Mini International Neuropsychiatric Interview (MINI) and the Hamilton Depression Rating Scale (HAM-D). Peripheral blood was drawn, and plasma levels of adipokines (adiponectin, leptin, and resistin) were measured by enzyme-linked immunoassay (ELISA).
People with TLE presented higher leptin and lower adiponectin and resistin levels in comparison with controls. The levels of these adipokines correlated negatively with illness length but not with other clinical parameters. In a binary logistic regression model, higher leptin and lower adiponectin levels remained as significant predictors of TLE diagnosis.
These results corroborate the view that TLE is a multisystemic condition associated with low-grade inflammation.
颞叶癫痫（TLE）患者在发作间期存在持续的低度炎症状态。脂肪因子是由脂肪组织产生的细胞因子，可影响炎症反应。本研究旨在评估TLE患者与对照组相比血浆中脂肪因子的水平。此外，我们试图研究脂肪因子水平是否与TLE的临床参数相关。
本研究纳入40例TLE患者和40例对照。所有参与者均接受临床评估，包括迷你国际神经精神访谈（MINI）和汉密尔顿抑郁量表（HAM-D）。采集外周血，采用酶联免疫吸附测定（ELISA）法测定血浆中脂肪因子（脂联素、瘦素和抵抗素）的水平。
与对照组相比，TLE患者的瘦素水平较高，脂联素和抵抗素水平较低。这些脂肪因子的水平与病程呈负相关，但与其他临床参数无关。在二元逻辑回归模型中，较高的瘦素水平和较低的脂联素水平仍然是TLE诊断的重要预测因素。
这些结果证实了TLE是一种与低度炎症相关的多系统疾病的观点。
