Vieira Érica L M, de Oliveira Guilherme N M, Lessa João Marcelo K, Gonçalves Ana Paula, Sander Josemir W, Cendes Fernando, Teixeira Antônio Lúcio
Neuroscience Division, Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Epilepsy Treatment Advanced Centre (NATE), Felício Rocho Hospital, Belo Horizonte, MG, Brazil; Medicine School, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG, Brazil.
Epilepsy Behav. 2015 Dec;53:131-4. doi: 10.1016/j.yebeh.2015.09.035. Epub 2015 Nov 11.
Inflammatory mediators such as cytokines are likely to contribute to the pathophysiology of epilepsy. Proinflammatory cytokines are also associated with mood disorders, such as major depression. As people with temporal lobe epilepsy (TLE) are at an increased risk of mood disorders, we attempted to evaluate peripheral levels of IL-1β in people with TLE with depression and people with TLE without depression and in healthy controls. In a cross-sectional study, we compared three groups: 21 people with TLE without depression (TLE D-), 18 people with TLE with depression (TLE D+), and 31 controls without depression. A structured clinical interview (MINI-Plus) was used to diagnose current depression, and the Hamilton Depression Rating Scale (HAM-D) was used to quantify depressive symptoms. Plasma levels of IL-1β were significantly higher in people with TLE with depression than in controls (p=0.004) or people with TLE without depression (p=0.006). Interleukin-1beta levels positively correlated with HAM-D scores (Spearman's rho=0.381, p=0.017) in people with TLE. Higher levels of IL-1β in TLE seem to be associated with depression.
细胞因子等炎症介质可能参与癫痫的病理生理过程。促炎细胞因子也与情绪障碍有关，如重度抑郁症。由于颞叶癫痫（TLE）患者患情绪障碍的风险增加，我们试图评估伴有抑郁症的TLE患者、不伴有抑郁症的TLE患者以及健康对照者外周血中IL-1β的水平。在一项横断面研究中，我们比较了三组：21例不伴有抑郁症的TLE患者（TLE D-）、18例伴有抑郁症的TLE患者（TLE D+）和31例无抑郁症的对照者。采用结构化临床访谈（MINI-Plus）诊断当前抑郁症，并使用汉密尔顿抑郁量表（HAM-D）量化抑郁症状。伴有抑郁症的TLE患者血浆IL-1β水平显著高于对照组（p=0.004）或不伴有抑郁症的TLE患者（p=0.006）。在TLE患者中，白细胞介素-1β水平与HAM-D评分呈正相关（Spearman秩相关系数=0.381，p=0.017）。TLE患者中较高水平的IL-1β似乎与抑郁症有关。
