Dzien A, Drexel H, Hopferwieser T, Patsch J R, Braunsteiner H
Universitätsklinik für Innere Medizin, Innsbruck.
Dtsch Med Wochenschr. 1988 Oct 28;113(43):1669-72. doi: 10.1055/s-2008-1067869.
The effect on fat metabolism of an intensified insulin treatment regimen was tested in 23 type I diabetics and compared with that of conventional insulin treatment. Definite improvement in blood glucose levels was found after a one-year intensified treatment schedule (HbA1 of 8.1% under intensified treatment, compared with 10.6% under conventional treatment). The intensified treatment schedule also resulted in a significant reduction in plasma triglycerides from an average of 114 mg/dl to 94 mg/dl (p less than 0.05), at the same time the plasma HDL-cholesterol levels increased. Plasma concentrations of total cholesterol and LDL-cholesterol remained unchanged. Thus intensified insulin treatment was shown to improve glucose metabolism, lower HDL-cholesterol and in this way improve the risk profile for macroangiopathy.
对23名I型糖尿病患者测试了强化胰岛素治疗方案对脂肪代谢的影响，并与传统胰岛素治疗进行了比较。经过一年的强化治疗方案后，血糖水平有了明显改善（强化治疗下糖化血红蛋白为8.1%，而传统治疗下为10.6%）。强化治疗方案还导致血浆甘油三酯从平均114毫克/分升降至94毫克/分升，有显著降低（p小于0.05），同时血浆高密度脂蛋白胆固醇水平升高。总胆固醇和低密度脂蛋白胆固醇的血浆浓度保持不变。因此，强化胰岛素治疗被证明可改善葡萄糖代谢，降低高密度脂蛋白胆固醇，并以此改善大血管病变的风险状况。
