Wilson D P, Fesmire J D, Endres R K, Blackett P R
South Med J. 1985 Jun;78(6):636-8. doi: 10.1097/00007611-198506000-00004.
Sixteen subjects with insulin-dependent diabetes mellitus were studied to determine whether changes in plasma lipids and apolipoproteins follow intensified control using preprandial doses of regular insulin with an additional dose of NPH insulin before bedtime. The mean total dialy dose of insulin was increased from 1.03 +/- 0.09 to 1.17 +/- 0.44 units/kg throughout the six-month period. Levels of HDL-cholesterol and apolipoprotein A-I increased without significant changes in hemoglobin A1 (HbA1), triglyceride, or cholesterol. These findings suggest that increases in HDL-cholesterol and apolipoprotein A-I were a result of the intensified insulin delivery.
对16名胰岛素依赖型糖尿病患者进行了研究，以确定在采用餐前注射普通胰岛素并在睡前追加一次中性鱼精蛋白锌胰岛素（NPH胰岛素）的强化治疗方案后，血浆脂质和载脂蛋白是否会发生变化。在整个6个月的研究期间，胰岛素的平均每日总剂量从1.03±0.09单位/千克增加到了1.17±0.44单位/千克。高密度脂蛋白胆固醇（HDL-胆固醇）和载脂蛋白A-I水平升高，而糖化血红蛋白（HbA1）、甘油三酯或胆固醇水平无显著变化。这些研究结果表明，HDL-胆固醇和载脂蛋白A-I的升高是强化胰岛素治疗的结果。
