Department of Neurology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha 410000, China.
Department of Neurology, Brain Hospital of Hunan Province, Changshsa 410000, China.
Rev Neurosci. 2019 Jul 26;30(5):477-484. doi: 10.1515/revneuro-2018-0056.
Alzheimer's disease (AD) is a neurodegenerative disease with progressive cognitive impairment. It is the most common type of senile dementia, accounting for 65%-70% of senile dementia [Alzheimer's Association (2016). 2016 Alzheimer's disease facts and figures. Alzheimers Dement. 12, 459-509]. At present, the pathogenesis of AD is still unclear. It is considered that β-amyloid deposition, abnormal phosphorylation of tau protein, and neurofibrillary tangles are the basic pathological changes of AD. However, the role of neurovascular unit damage in the pathogenesis of AD has been attracting more and more attention in recent years. The composition of neurovascular unit and the role of neurovascular unit damage in the occurrence and development of AD were reviewed in this paper.
阿尔茨海默病（AD）是一种进行性认知障碍的神经退行性疾病。它是最常见的老年痴呆类型，占老年痴呆症的 65%-70%[阿尔茨海默病协会（2016）。2016 年阿尔茨海默病事实和数据。Alzheimers Dement. 12, 459-509]。目前，AD 的发病机制尚不清楚。人们认为β-淀粉样蛋白沉积、tau 蛋白异常磷酸化和神经纤维缠结是 AD 的基本病理改变。然而，近年来，神经血管单元损伤在 AD 发病机制中的作用越来越受到关注。本文综述了神经血管单元的组成及其在 AD 发生发展中的作用。
