Whitwell K E, Harris P, Farrington P G
Pathology Unit, Animal Health Trust, Newmarket, Suffolk.
Equine Vet J. 1988 Sep;20(5):357-63. doi: 10.1111/j.2042-3306.1988.tb01545.x.
Four out of 12 horses grazing a field in Berkshire, England, suffered a prostrating illness and died within 12 to 72 h. Serum biochemical abnormalities, including markedly elevated muscle enzymes, were demonstrated and at post mortem widespread myodegeneration was found in both skeletal muscle and myocardium. Urine analysis revealed myoglobinuria, and renal changes were seen histologically. Although similar pathologically, the clinical syndrome and circumstances of the outbreak were not typical of equine exertional rhabdomyolysis (EER). The outbreak bore a striking resemblance to other reported sporadic outbreaks of an atypical myoglobinuria occurring in grazing horses. A number of potential aetiological and contributory factors (including herbicide toxicity) were considered, but the aetiology remains unresolved.
在英格兰伯克郡一块田地里吃草的12匹马中，有4匹患上重病，在12至72小时内死亡。血清生化指标异常，包括肌肉酶显著升高，尸检发现骨骼肌和心肌均有广泛的肌变性。尿液分析显示有肌红蛋白尿，组织学检查可见肾脏变化。尽管病理表现相似，但此次疫情的临床综合征和情况并非典型的马运动性横纹肌溶解症（EER）。此次疫情与其他报道的放牧马匹中发生的非典型肌红蛋白尿的散发性疫情极为相似。考虑了一些潜在的病因和促成因素（包括除草剂毒性），但病因仍未明确。
