剖宫产术后药物性血栓预防的疗效和安全性：系统评价和荟萃分析。
The efficacy and safety of pharmacologic thromboprophylaxis following caesarean section: A systematic review and meta-analysis.
机构信息
Pharmaceutical Department, Shandong Provincial Qianfoshan Hospital, Jinan,China.
出版信息
PLoS One. 2018 Dec 10;13(12):e0208725. doi: 10.1371/journal.pone.0208725. eCollection 2018.
OBJECTIVE
Our purpose is to evaluate the efficacy and safety of pharmacologic thromboprophylaxis following caesarean section (CS).
METHODS
We searched PubMed, Embase, and the Cochrane Library. Then the systematic review was performed by analysing studies that met the eligibility criteria.
RESULTS
Seven studies with 1243 participants were included, including 6 RCTs and 1 prospective cohort. Results from the meta-analysis showed that low molecular weight heparin (LMWH) was associated with no obvious decrease in the risk of thrombus compared with UHF and negative control. However, LMWH was observed to be associated with a definite increase in the risk of bleeding or haematomas in comparison to negative control (RR: 8.47, CI: 1.52-47.11).
CONCLUSION
According to current evidences, the efficacy of pharmacologic thromboprophylaxis which increases the risk of bleeding or hematomas remains controversial.
目的
评估剖宫产术后药物性血栓预防的疗效和安全性。
方法
我们检索了 PubMed、Embase 和 Cochrane Library。然后，通过分析符合纳入标准的研究进行系统评价。
结果
纳入了 7 项研究，共 1243 名参与者，包括 6 项 RCT 和 1 项前瞻性队列研究。荟萃分析结果表明，与 UFH 和阴性对照相比，低分子肝素（LMWH）并未明显降低血栓形成风险。然而，与阴性对照相比，LMWH 观察到出血或血肿风险明显增加（RR：8.47，CI：1.52-47.11）。
结论
根据现有证据，增加出血或血肿风险的药物性血栓预防的疗效仍存在争议。
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