Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, and WIRM Institute for Research and Medicine , The Scripps Research Institute , La Jolla , California 92037 , United States.
J Am Chem Soc. 2019 Feb 6;141(5):1798-1806. doi: 10.1021/jacs.8b09756. Epub 2018 Dec 11.
The present United States opioid crisis requires urgent and innovative scientific intervention. This perspective highlights a role for the chemical sciences by expounding upon three key research areas identified as priorities by the National Institute on Drug Abuse (NIDA). Specifically, important advances in chemical interventions for overdose reversal, strategies for opioid use disorder (OUD) treatment, including immunopharmacotherapies, and next-generation alternatives for pain management will be discussed. Ultimately, progress made will be presented in light of remaining challenges for the field.
目前美国的阿片类药物危机需要紧急和创新的科学干预。本观点通过阐述国家药物滥用研究所（NIDA）确定的三个优先重点研究领域，强调了化学科学的作用。具体而言，将讨论用于逆转过量用药的化学干预、阿片类药物使用障碍（OUD）治疗策略（包括免疫药理学疗法）以及用于疼痛管理的下一代替代方案方面的重要进展。最终，将根据该领域的剩余挑战来呈现取得的进展。
