对映选择性合成 14-羟基-6-氧代吗啡烷。
Enantioselective synthesis of 14-hydroxy-6-oxomorphinans.
机构信息
The GlaxoSmithKline Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Jubilee Campus, Triumph Road, Nottingham, NG7 2TU, UK.
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
出版信息
Chem Commun (Camb). 2024 Jun 6;60(47):6007-6010. doi: 10.1039/d4cc01788a.
Abstract
The enantioselective synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.
摘要
描述了具有药理重要性的 14-羟基-6-氧吗啡喃的对映选择性合成。使用该路线制备了 4,5-去氧纳曲酮和 4,5-去氧纳洛酮，并测量了它们对阿片受体的生物活性。
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