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Intravascular ultrasound and histopathological observations in a patient with very late sirolimus-eluting stent thrombosis.西罗莫司洗脱支架极晚期血栓形成患者的血管内超声及组织病理学观察
J Cardiol Cases. 2012 May 15;6(5):e126-e129. doi: 10.1016/j.jccase.2012.04.007. eCollection 2012 Nov.
2
Correlation of intravascular ultrasound findings with histopathological analysis of thrombus aspirates in patients with very late drug-eluting stent thrombosis.极晚期药物洗脱支架血栓形成患者血管内超声检查结果与血栓抽吸物组织病理学分析的相关性
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3
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Coronary evaginations are associated with positive vessel remodelling and are nearly absent following implantation of newer-generation drug-eluting stents: an optical coherence tomography and intravascular ultrasound study.冠状动脉迂曲与正性重构相关,且在植入新一代药物洗脱支架后几乎不存在:光学相干断层成像和血管内超声研究。
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Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement.西罗莫司洗脱支架置入术后极晚期支架内血栓形成的系列血管内超声评估
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Acute coronary syndrome is an independent risk factor for late incomplete stent apposition after sirolimus-eluting stent implantation.急性冠状动脉综合征是西罗莫司洗脱支架植入术后晚期支架贴壁不全的独立危险因素。
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Stent malapposition after sirolimus-eluting and bare-metal stent implantation in patients with ST-segment elevation myocardial infarction: acute and 9-month intravascular ultrasound results of the MISSION! intervention study.ST段抬高型心肌梗死患者接受西罗莫司洗脱支架和裸金属支架植入术后的支架贴壁不良:MISSION!干预研究的急性和9个月血管内超声结果
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Pathogenesis of late in-stent thrombosis after treatment with drug-eluting stents.药物洗脱支架治疗后晚期支架内血栓形成的发病机制。
J Cardiol Cases. 2012 Sep 18;6(5):e158-e160. doi: 10.1016/j.jccase.2012.08.005. eCollection 2012 Nov.
2
Association of localized hypersensitivity and in-stent neoatherosclerosis with the very late drug-eluting stent thrombosis.局部超敏反应及支架内新生动脉粥样硬化与药物洗脱支架极晚期血栓形成的相关性
PLoS One. 2014 Nov 25;9(11):e113870. doi: 10.1371/journal.pone.0113870. eCollection 2014.

本文引用的文献

1
Characteristics and predictors of drug-eluting stent thrombosis: results from the multicenter 'Korea Stent Thrombosis (KoST)' registry.药物洗脱支架血栓形成的特征和预测因素:多中心“韩国支架血栓形成(KoST)”登记研究结果。
Circ J. 2011;75(7):1626-32. doi: 10.1253/circj.cj-10-1160. Epub 2011 May 28.
2
Drug-eluting stent: importance of clinico-pathological correlations.药物洗脱支架:临床病理相关性的重要性。
Circ J. 2011;75(7):1548-58. doi: 10.1253/circj.cj-11-0393. Epub 2011 May 27.
3
Contrast staining outside the sirolimus-eluting stent leading to coronary aneurysm formation: a case of very late stent thrombosis associated with hypersensitivity reaction.西罗莫司洗脱支架外的对比剂染色导致冠状动脉瘤形成:一例与超敏反应相关的极晚期支架血栓形成病例。
Circ Cardiovasc Interv. 2011 Feb 1;4(1):e1-3. doi: 10.1161/CIRCINTERVENTIONS.110.958090.
4
Clinical outcomes and the risk factors of coronary artery aneurysms that developed after drug-eluting stent implantation.药物洗脱支架置入后发生冠状动脉瘤的临床结果及危险因素。
Circ J. 2011;75(4):861-7. doi: 10.1253/circj.cj-10-0635. Epub 2011 Jan 18.
5
The evolving role of inflammatory biomarkers in risk assessment after stent implantation.支架植入术后炎症生物标志物在风险评估中的作用演变。
J Am Coll Cardiol. 2010 Nov 23;56(22):1783-93. doi: 10.1016/j.jacc.2010.06.045.
6
Correlation of intravascular ultrasound findings with histopathological analysis of thrombus aspirates in patients with very late drug-eluting stent thrombosis.极晚期药物洗脱支架血栓形成患者血管内超声检查结果与血栓抽吸物组织病理学分析的相关性
Circulation. 2009 Aug 4;120(5):391-9. doi: 10.1161/CIRCULATIONAHA.109.854398. Epub 2009 Jul 20.
7
Coronary aneurysms after drug-eluting stent implantation: clinical, angiographic, and intravascular ultrasound findings.药物洗脱支架植入术后冠状动脉瘤:临床、血管造影及血管内超声检查结果
J Am Coll Cardiol. 2009 Jun 2;53(22):2053-60. doi: 10.1016/j.jacc.2009.01.069.
8
Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation.西罗莫司洗脱支架植入术后的抗血小板治疗与支架内血栓形成
Circulation. 2009 Feb 24;119(7):987-95. doi: 10.1161/CIRCULATIONAHA.108.808311. Epub 2009 Feb 9.
9
Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents.药物洗脱支架成功植入后血栓形成的发生率、预测因素及转归
JAMA. 2005 May 4;293(17):2126-30. doi: 10.1001/jama.293.17.2126.
10
Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious?西罗莫司洗脱支架所致局部超敏反应和迟发性冠状动脉血栓形成:我们应谨慎对待吗?
Circulation. 2004 Feb 17;109(6):701-5. doi: 10.1161/01.CIR.0000116202.41966.D4. Epub 2004 Jan 26.

西罗莫司洗脱支架极晚期血栓形成患者的血管内超声及组织病理学观察

Intravascular ultrasound and histopathological observations in a patient with very late sirolimus-eluting stent thrombosis.

作者信息

Sonoda Shinjo, Okazaki Masahiro, Iwataki Mai, Kashiyama Kuninobu, Muraoka Yoshitaka, Kamezaki Fumihiko, Tsuda Yuki, Araki Masaru, Shimajiri Kouhei, Inoue Katsumi, Otsuji Yutaka

机构信息

Department of Cardiovascular Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

出版信息

J Cardiol Cases. 2012 May 15;6(5):e126-e129. doi: 10.1016/j.jccase.2012.04.007. eCollection 2012 Nov.

DOI:10.1016/j.jccase.2012.04.007
PMID:30533089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269348/
Abstract

This case report describes an autopsy case of very late stent thrombosis, which was associated with intravascular ultrasound findings of late-acquired stent malapposition with thrombotic materials and marked positive vascular remodeling at the site of the sirolimus-eluting stent implantation. Histopathological examination showed both destructive and proliferative reactions had occurred in the same stented coronary arterial wall 44 months after sirolimus-eluting stent implantation. Long-lasting severe local inflammation beyond healing reaction, causing vessel enlargement, may be related to very late stent thrombosis.

摘要

本病例报告描述了一例极晚期支架血栓形成的尸检病例,其与血管内超声检查结果相关,显示晚期获得性支架贴壁不良并伴有血栓形成物质,以及西罗莫司洗脱支架植入部位明显的阳性血管重塑。组织病理学检查显示,在西罗莫司洗脱支架植入44个月后,同一冠状动脉支架置入部位的血管壁同时出现了破坏和增殖反应。超出愈合反应的长期严重局部炎症导致血管扩张,可能与极晚期支架血栓形成有关。