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一名老年男性在接受卡介苗膀胱灌注治疗膀胱癌时骨髓增生异常综合征出现短暂自发缓解：病例报告及文献复习

Transitory Spontaneous Remission of Myelodysplasia in an Elderly Man while Receiving Intravesical Bacillus Calmette-Guérin for Bladder Cancer: A Case Report and Review of the Literature.

作者信息

Murray Nigel P, Fuentealba Cynthia, Salazar Isidora, Salazar Aníbal, Lopez Marco Antonio, Minzer Simona

机构信息

Consultant Hemologist, Depto. Medicine, Hospital de Carabineros de Chile, Simón Bolívar 2200, Ñuñoa 7770199, Santiago, Chile.

Professor Hematology, Faculty of Medicine, University Finis Terrae, Av Pedro de Valdivia 1509, Providencia, Santiago, Chile.

出版信息

Case Rep Hematol. 2018 Nov 11;2018:9750532. doi: 10.1155/2018/9750532. eCollection 2018.

DOI:10.1155/2018/9750532
PMID:30534450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6252232/
Abstract

Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. We present a patient with transfusion-dependent myelodysplasia whose blood counts normalized during treatment with intravesical BCG for bladder cancer. After finishing treatment, the patient became transfusion dependent once more. We discuss possible mechanisms to explain this case report.

摘要

骨髓发育异常是一种以进行性血细胞减少为特征的克隆性疾病。膀胱内灌注卡介苗是浅表性膀胱癌的标准免疫疗法。我们报告一例依赖输血的骨髓发育异常患者，其在接受膀胱癌膀胱内卡介苗治疗期间血细胞计数恢复正常。治疗结束后，患者再次依赖输血。我们讨论了解释该病例报告的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/e2b0b06d92e5/CRIHEM2018-9750532.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/c19acbc01013/CRIHEM2018-9750532.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/21407f06ad1e/CRIHEM2018-9750532.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/93086bbd8b78/CRIHEM2018-9750532.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/b5062bb548aa/CRIHEM2018-9750532.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/2ddb8066e163/CRIHEM2018-9750532.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/d6ae38830978/CRIHEM2018-9750532.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/e2b0b06d92e5/CRIHEM2018-9750532.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/c19acbc01013/CRIHEM2018-9750532.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/21407f06ad1e/CRIHEM2018-9750532.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/93086bbd8b78/CRIHEM2018-9750532.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/b5062bb548aa/CRIHEM2018-9750532.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/2ddb8066e163/CRIHEM2018-9750532.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/d6ae38830978/CRIHEM2018-9750532.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54ea/6252232/e2b0b06d92e5/CRIHEM2018-9750532.007.jpg

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本文引用的文献

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Spontaneous Remission in an Older Patient with Relapsed ITD Mutant AML.一名复发的ITD突变型急性髓系白血病老年患者的自发缓解
Case Rep Hematol. 2016;2016:1259759. doi: 10.1155/2016/1259759. Epub 2016 Dec 29.
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Haemophagocytic syndrome after intravesical bacille Calmette-Guérin instillation.膀胱内灌注卡介苗后发生噬血细胞综合征。
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Fever of unknown origin and pancytopenia caused by culture-proven delayed onset disseminated bacillus Calmette-Guerin (BCG) infection after intravesical instillation.
膀胱内灌注后经培养证实的迟发性播散性卡介苗（BCG）感染所致不明原因发热和全血细胞减少。
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[Urinary bladder cancer producing granulocyte-colony stimulating factor: a case report and review of the literature].[产生粒细胞集落刺激因子的膀胱癌：一例报告并文献复习]
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