Morisada Tohru, Saika Kumiko, Saito Eiko, Kono Kanako, Saito Hiroshi, Aoki Daisuke
Department of Obstetrics and Gynecology, Keio University School of Medicine.
Screening Assessment and Management Division, Center for Public Health Sciences, National Cancer Center.
Jpn J Clin Oncol. 2018 May 1;48(5):495-498. doi: 10.1093/jjco/hyy025.
In cervical cancer screening, several trials have shown that human papillomavirus (HPV) testing or combined HPV testing and cytology leads to earlier detection of cervical intraepithelial neoplasia Grade 3 or worse (CIN3+) compared with cytology alone. However, the availability of similar evidence in our country remains limited. In 2013, 34 local governments were selected to administer a cervical cancer screening program utilizing either cytology alone or in combination with HPV testing. We planned a cohort study to assess the effectiveness of HPV testing as a modality for cervical cancer screening. The primary outcome of this study was the incidence of CIN3+ in each group, as well as to assess the risks and benefits of receiving screening for women in both groups. These results will contribute to elucidating the details of the positive and negative impacts of introducing HPV testing into a population-based cervical cancer screening program in Japan.
在宫颈癌筛查中，多项试验表明，与人乳头瘤病毒（HPV）检测或HPV检测与细胞学检查相结合相比，单独进行细胞学检查会导致宫颈上皮内瘤变3级或更严重病变（CIN3+）的检测时间更晚。然而，我国类似证据的可得性仍然有限。2013年，选取了34个地方政府实施一项宫颈癌筛查项目，该项目采用单独的细胞学检查或与HPV检测相结合的方式。我们计划开展一项队列研究，以评估HPV检测作为宫颈癌筛查方式的有效性。本研究的主要结果是每组中CIN3+的发病率，以及评估两组女性接受筛查的风险和益处。这些结果将有助于阐明在日本基于人群的宫颈癌筛查项目中引入HPV检测的正负影响细节。
