Kraeuter Ann-Katrin, Guest Paul C, Sarnyai Zoltán
Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia.
Discipline of Biomedicine, College of Public Health, Medicine and Veterinary Sciences, James Cook University, Townsville, QLD, Australia.
Methods Mol Biol. 2019;1916:81-85. doi: 10.1007/978-1-4939-8994-2_6.
Obsessive-compulsive disorder (OCD) can occur in several psychiatric illnesses such as autism spectrum disorders (ASD) and it is more prevalent in children. This condition is characterized by repeated and apparently meaningless behaviors such as frequent hand washing, counting, tapping, and rocking. This can disrupt normal socialization and in some cases lead to self-harm. Therefore there is interest in developing more effective therapies for individuals suffering from these conditions. This chapter describes how to conduct the mouse marble burying test as a sensitive measure of compulsive behaviors.
强迫症（OCD）可发生于多种精神疾病中，如自闭症谱系障碍（ASD），且在儿童中更为普遍。这种病症的特征是反复出现且明显无意义的行为，如频繁洗手、数数、轻拍和摇晃身体。这会扰乱正常的社交，在某些情况下还会导致自我伤害。因此，人们有兴趣为患有这些病症的个体开发更有效的治疗方法。本章描述了如何进行小鼠大理石埋藏试验，作为一种衡量强迫行为的敏感方法。
